Step-by-step analysis walkthrough

Step-by-step analysis walkthrough#

This section provides a detailed, step-by-step demonstration of the preprocessing, analysis, and handling of individual samples in single-cell spatial transcriptomics data using InSituPy. Each part of the tutorial builds upon the previous one, and it is recommended to follow the steps sequentially from top to bottom to ensure proper functionality.

01: Automated image registration

Tutorial showing how to use the automated image registration pipeline to register histological stainings or IF stainings performed on the same slide as the scST assay.

Tutorial on how to use the automated image registration pipeline in `InSituPy`.
02: First analysis steps

Tutorial with introduction into first steps of analysis including filtering, preprocessing and dimensionality reduction.

Data preprocessing and analysis
03: Annotations in InSituPy

Tutorial introducing how to import annotations and regions from external sources like QuPath or add them in the napari viewer.

Working with histological annotations and regions
04: Crop data

Tutorial showing how to crop data.

Cropping the data
05: Cell type annotation

Tutorial showing different options to perform cell type annotation.

Cell type annotation
06: Explore gene expression along an axis

Demonstration on how to explore gene expression along an axis of the dataset.

Investigate gene expression and cell density along an axis